By 2099
There is a strong trend toward a merger of human thinking with the world of machine intelligence that the human species initially created.
There is no longer any clear distinction between humans and computers.
Most conscious entities do not have a permanent physical presence.
Machine-based intelligences derived from extended models of human intelligence claim to be human, although their brains are not based on carbon-based cellular process, but rather electronic and photonic equivalents. Most of these intelligences are not tied to a specific computational process unit. The number of software-based humans vastly exceeds those still using native neuron-cell-based computation.